Yvonne McGrotty - Case study in a Persian cat

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Case Study - 1
by Yvonne McGrotty BVMS, CertSAM, DipECVIM-CA, MRCVS.

 
 Can you identify this?
[picture courtesy of www.medicinereferrals.co.uk]


CLINICAL PATHOLOGY
Haematology mostly unremarkable. Some mild and non-specific biochemical changes were noted. A bile acid stimulation test was performed and suggested adequate liver function in this cat (Bile acids >30 considered to be clinically significant). Clotting times were unremarkable (see below).


DISCUSSION 

 DIAGNOSIS
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BIOCHEMISTRY
  Dynamic Bile Acids
Bile Acids  2.5  umol/l  0.0 - 15.0 
Total Bilirubin  5.0  umol/l  0.0 - 10.0 
Bile Acids post feed  H 29.7  umol/l  0.0 - 15.0 

  Full Blood Count
WBC  6.7  x10^9/l  4.0 - 15.0   
RBC  7.41  x10^12/l  5.50 - 10.00   
Haemoglobin  8.5  g/dl  8.0 - 15.0   
PCV  28.0  %  27.0 - 50.0   
MCV  L 37.8  fl   40.0 - 55.0   
MCH  L 11.5  pg  13.0 - 17.0   
MCHC  L 30.4  g/dl  31.0 - 34.0   
Platelets  449   x10^9/l   200 - 600   
  Range x10^9/l Range 
Neutrophils  45  45 -75  3.0  2.5 - 12.5 
Lymphocytes  H 52  25 -33  3.5  1.5 - 7.0 
Monocytes  1 0 - 4   0.1   0.0 - 0.8 
Eosinophils  L 2  4 -12  0.1  0.0 - 1.5 
Basophils  0  0 -1  0.0   

 Film Film confirms platelet count      
  Burr cells +     
  Schistocytes +     
  Acanthocytes +     
  Occasional microcyte seen     

Total Protein 64.3  g/l   54.0 - 78.0   
Albumin  30.3  g/l  21.0 - 39.0   
Urea  7.5  mmol/l   6.0 - 10.0   
Creatinine  172  umol/l  80 - 180   
Total Bilirubin  5.0  umol/l  0.0 - 10.0   
ALP  29  u/l@37C  0 - 40   
ALT  H 48  u/l@37C  0 - 20   
AST  31  u/l@37C  0 - 69   
Gamma GT  2.0  u/l@37C  0.0 - 27.0   
Calcium  2.43  mmol/l  1.60 - 3.00   
Phosphate  1.72 mmol/l  1.40 - 2.60   
Sodium  H 157  mmol/l  120 - 155   
Potassium  4.40  mmol/l  3.60 - 5.60   
Chloride  122  mmol/l  112 - 129   
Glucose - Random     No oxf sample receive   
Triglycerides 0.46  mmol/l   0.22 - 1.24   
Cholesterol  2.5  mmol/l   1.9 - 3.9   
HAEMATOLOGY 
PT 10  secs   
APTT  17  secs   
PKD  Positive     
CYTOLOGY
Fluid Analysis - from free abdominal fluid 
Fluid Protein  39.3 g/l   
Fluid Albumin  18.8 g/l  
Fluid Globulin  20.5  g/l   
Fluid Albumin:Globulin  0.9     
Fluid Specific Gravity  1.030     
WBC  0.91   
RBC  0.01  
Abdominocentesis was performed and a straw-coloured fluid collected for analysis.
The free abdominal fluid was a modified transudate containing non-degenerate neutrophils and occasional reactive mesothelial cells (see below).    
Surgical Exploration
The abdomen was surgically explored under general anaesthesia. The abdomen contained a significant quantity of straw-coloured free fluid. The liver was massively enlarged and cystic.

  Figure 3

 Figure 4 
The left medial and proximal left lateral, quadrate, right medial lobes and papillary process of the caudate lobe were diffusely affected. The right lateral lobe, and distal extremity of left lateral lobe had a more normal appearance, although the liver tissue was firm and had a nodular appearance.
Both kidneys were identified at surgery and both had cystic changes. The rest of the abdomen was unremarkable. The stomach was unaffected but was being compressed by the mass. Two liver biopsies were obtained were sent for histology. Surgical resection of the mass was not possible, but numerous cysts were drained resulting in a 30-40% reduction in the size of the liver. The cat recovered uneventfully from anaesthesia and was discharged 24 hours later with an S-Adenosyl methionine supplement. 
One of the liver cysts was aspirated and fluid results are as follows:
Fluid Analysis    
Fluid Protein   1.4  g/l     
Fluid Albumin   0.5  g/l     
Fluid Globulin   0.9  g/l     
Fluid Albumin:Globulin   0.6     
Fluid Specific Gravity   1.010      
WBC   0.19  x10^9/l     
 RBC   0.04  x10^12/l      
Cytological examination was consistent with a cystic fluid with evidence of both previous and iatrogenic haemorrhage. 
Histopathology was consistent with multiple biliary cysts with some areas of nodular hyperplasia with vacuolar change. There was no evidence of neoplasia or inflammation in any of the sections. 

DISCUSSION 

 DIAGNOSIS

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