Case Study 02 - 12yr Old [F] Staffordshire Bull Terrier

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Case Study - 2 - Path Report
by Beverley Highfield BSc. (Hons). St. Helens Laboratory Manager

Severe anaemia, appears regenerative but reticulocyte count is advisable for verification of regenerative response.
Blood transfusion may well be indicated depending on clinical signs.
Left shift neutrophilia is suggestive of inflammation or infection.
The presence of a few circulating mast cells is very non-specific and can be seen normally, but can also occur with mast cell tumours, allergy/hypersensitivity responses and parasitism.
Severe hypoalbuminemia could be caused by renal (e.g. amyloidosis, glomerulone- phropathy) or GI losses (e.g. IBD, lymphangiectasia, lymphoma) and reduced hepatic production.
In view of the history and concurrent anaemia, GI haemorrhage is perhaps the most likely cause of panhypoproteinemia in this case.
The change in calcium and phosphate commonly occur as artefacts.
Uraemia may be pre-renal with creatinine at this level, and measurement of USG should assist further interpretation.
Marked increase in ALT could be caused by extra-hepatic disease, although at this level primary hepatic pathology is more probable.
Marked elevation in CK could be due to the exertion associated with severe vomiting.
If rodenticide ingestion is suspected then suggest checking clotting times (APTT & PT).

 

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